Stop Fighting Kinetics: A Three-Stage Route to ∆9-THC via Regioselective Elimination CBD ISOMERIZATION HOW TO: The Problem Every Scale-Up Chemist Knows:If you have ever run an acid-catalyzed cyclization of CBD in a 50L reactor and pulled HPLC results showing a 5:1 ∆8:∆9 ratio, you already understand the frustration. The textbooks promise that lower temperature favors [...]