Cannabis Chemistry - WKU Consulting

Is Yeast Replacing Cannabis? De Novo Cannabinoid Biosynthesis Explained

Cannabinoid Biosynthesis Is Changing Everything Cannabinoid biosynthesis is no longer a theoretical concept confined to academic papers â it's an industrial reality that's forcing the entire cannabis industry to pay attention. Scientists have successfully engineered yeast to produce THC, CBD, and rare cannabinoids like THCV and CBGV from nothing more than simple sugars. No plants. [...]

By WKU Consulting|2026-03-08T15:11:21+00:00March 8th, 2026|Cannabis Chemistry|Comments Off

How to Convert CBD to THC at Home: Delta 9 & Delta 8 Isomerization SOP

CBD converts to THC through acid-catalyzed isomerization: a Lewis or Bronsted acid rearranges the molecular structure of CBD (C21H30O2) into delta-9-THC or delta-8-THC by cyclizing the open ring. The most common catalyst is para-toluenesulfonic acid (pTSA) at 0.1M concentration in dichloromethane at 80C for 3-4 hours, yielding 85-92% delta-9-THC with 3-7% delta-8 as a byproduct. [...]

By WKU Consulting|2026-06-01T07:25:59+00:00February 28th, 2026|Cannabis Chemistry|Comments Off

How to Make Delta 8 THC from CBD: Complete SOP Using a Short Path Distillation System

Learn how to convert CBD isolate into delta 8 THC using T-41 bleaching clay and a short path distillation system. Complete SOP with legality breakdown, equipment list, step-by-step procedure, and storage tips from WKU Consulting.

By WKU Consulting|2026-03-20T00:37:41+00:00February 27th, 2026|Cannabis Chemistry, Lab Techniques|Comments Off

Unlocking the Potential of CBDM/THCM: Methylation of CBD

The world of cannabinoids continues to expand, presenting innovative pathways to harness their potential. Among these is the process of methylation, a chemical modification technique that holds promise in altering the properties of cannabinoids. In particular, the methylation of Cannabidiol (CBD) to create CBDM using dimethylsulphate has piqued the interest of researchers and enthusiasts alike. [...]

By WKU Consulting|2026-03-06T22:29:03+00:00January 4th, 2024|Cannabis Chemistry|Comments Off

Unveiling the Potent Effects of 11-Hydroxy-Delta-9-Tetrahydrocannabinol (11-OH-THC)

When it comes to the green universe of cannabis, there's a star player that often hides in the shadows: 11-hydroxy-delta-9-tetrahydrocannabinol, or 11-OH-THC. This compound might not wear the crown like its cousin THC, but it's certainly making waves in the cannabis community. The Metabolic Magic Show Picture this: THC, the main act, enters the body [...]

By WKU Consulting|2026-03-06T22:29:14+00:00December 26th, 2023|Cannabis Chemistry|Comments Off

Boron Trifluoride (BF3) in Isomerization of CBD to Delta 9

Boron trifluoride (BF3) is a Lewis acid that is commonly used as a catalyst in the isomerization of CBD to other cannabinoids, such as THC. The process involves the use of BF3 to facilitate the rearrangement of atoms in the CBD molecule, leading to the formation of THC or other cannabinoids. The isomerization of CBD [...]

By WKU Consulting|2026-05-04T03:03:47+00:00January 16th, 2023|Cannabis Chemistry|Comments Off

Lewis Acids for cannabinoid isomerization

Lewis acids are a class of chemicals that can be used to catalyze the isomerization of CBD into other cannabinoids, such as THC. In this process, a Lewis acid acts as a catalyst to facilitate the rearrangement of the atoms in the CBD molecule, converting it into THC or other cannabinoids. The most common Lewis [...]

By WKU Consulting|2026-05-07T19:42:39+00:00January 12th, 2023|Cannabis Chemistry|1 Comment

How can a Lewis Acid make CBD go to THC?

Lewis acids are chemical compounds that are able to accept a pair of electrons to form a covalent bond. These compounds are commonly used as catalysts in organic synthesis, a process that involves the synthesis of organic compounds from simpler starting materials. One of the main advantages of Lewis acids is their ability to facilitate [...]

By WKU Consulting|2026-03-30T03:02:57+00:00December 30th, 2022|Cannabis Chemistry|1 Comment